Portfolio

 

Original Articles:

Interview Articles:



AWIS LA/VC Newsletter:

Editor-in-chief of the chapter newsletter since 2017 January. Our chapter is the winner of the 2017 Association for Women in Science Star Award.



Scientific Journal Publications:

We provided a first-in-kind mouse model to investigate viral oncogenesis induced by human gammaherpesvirus in the context of viral infection. We developed a recombinant herpesvirus that carries the Kaposi’s sarcoma herpesvirus (KSHV) G protein-coupled receptor. Within 6 months, mice infected with this recombinant herpesvirus developed angiogenic lesions that recapitulated human Kaposi’s sarcoma.
This is a video journal publication illustrating how we assessed the antiviral cytokine production both in vivo and ex vivo, using herpesvirus infection mouse model. Step-by-step experimental procedures are shown in the video.
Using KSHV GPCR-induced tumor models, we identified IKKε as a key molecule linking kGPCR to NF-κB activation. These observations support the notion that kGPCR nourishes chronic NF-κB activation. Thus, the kGPCR-induced tumorigenesis pathway was made clear.
The dependency of activated natural killer (NK) cells on the continuous support of exogenous interleukin (IL)-2 is a major obstacle for NK cell-mediated tumor therapy. We established an NK cell self-supporting autocrine system by anchoring IL-12 onto the primary NK cell membrane. This strategy prolonged the survival time of mice bearing melanoma metastases.


Conference Talks and Posters:

Bioluminescent Biosensors for Detecting Botulinum Neurotoxins. 54th Interagency Botulism Research Coordinating Committee (IBRCC) Meeting, Oct 2017 (Talk)

Bioluminescent Substrates for Detection of Botulinum Neurotoxins using Luciferase-specific Antibody Variable Domain Fusion Proteins. 53rd Interagency Botulism Research Coordinating Committee Conference, October 2016

Antibody Variable Domains as Intramolecular Luciferase Inhibitors for the Generation of Proteolysis-Activated Biosensors. 64th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, June 2016.

The IKKepsilon Kinase Relays Signal Transduction from Viral G Protein-coupled Receptor to NF-kappaB Activation and Tumorigenesis. 16th International Workshop on Kaposi’s Sarcoma Herpesvirus (KSHV) and Related Agents, July 2013   (Invited talk)

An IL-12/Shh-C Domain Fusion Protein-Based IL-12 Autocrine Loop for Sustained NK Cell Activation. 2nd American Association for Cancer Research International Conference on Frontiers in Basic Cancer Research, September 2011

Sustained Self-activation of NK Cells in vitro and in vivo by Expression of IL-12/Shh-C Fusion Proteins. 44th Annual Meeting of the Society for Leukocyte Biology, September 2011.